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Manual de Instrucciones
IM-106-880 Edición en Castellano
OCX 8800
Mayo 2005
3) A statistical "trend" was observed in the exposed population between the duration of exposure to RCF and a
decrease in some measures of pulmonary function. These observations are clinically insignificant. In other words,
if these observations were made on an individual employee, the results would be interpreted as being within the
normal range.
4) Pleural plaques (thickening along the chest wall) have been observed in a small number of employees who had
a long duration of employment. There are several occupational and non-occupational causes for pleural plaque. It
should be noted that plaques are not "pre-cancer" nor are they associated with any measurable effect on lung
function.
TOXICOLOGY
A number of studies on the health effects of inhalation exposure of ratsand hamsters are available. Rats were
exposed to RCF in a series of life-time nose-only inhalation studies. The animals were exposed to 30, 16, 9, and 3
mg/m3, which corresponds with approximately 200, 150, 75, and 25 fibers/cc. Animals exposed to 30 and 16
mg/m3 were observed to have developed a pleural and parenchymal fibroses; animals exposed to 9 mg/m3 had
developed a mild parenchymal fibrosis; animals exposed to the lowest dose were found to have the response
typically observed any time a material is inhaled into the deep lung. While a statistically significant increase in lung
tumors was observed following exposure to the highest dose, there was no excess lung cancers at the other
doses. Two rats exposed to 30 mg/m3 and one rat exposed to 9 mg/m3 developed masotheliomas. The
International Agency for Research on Cancer (IARC) reviewed the carcinogenicity data on man-made vitreous
fibers (including ceramic fiber, glasswool, rockwool, and slagwool) in 1987. IARC classified ceramic fiber, fibrous
glasswool and mineral wool (rockwool and slagwool) as possible human carcinogens (Group 2B).
EMERGENCY FIRST AID PROCEDURES
• EYE CONTACT - Flush eyes immediately with large amounts of water for approximately 15 minutes. Eye lids
should be held away from the eyeball to insure thorough rinsing. Do not rub eyes. Get medical attention if irritation
persists.
• INHALATION - Remove person from source of exposure and move to fresh air. Some people may be sensitive
to fiber induced irritation of the respiratory tract. If symptoms such as shortness of breath, coughing, wheezing or
chest pain develop, seek medical attention. If person experiences continued breathing difficulties, administer
oxygen until medical assistance can be rendered.
• INGESTION - Do not induce vomiting. Get medical attention if irritation persists.
• SKIN CONTACT - Do not rub or scratch exposed skin. Wash area of contact thoroughly with soap and water.
Using a skin cream or lotion after washing may be helpful. Get medical attention if irritation persists.
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